Overview
Infect more cells with TransDux™
Increase your transduction efficiencies with TransDux (Original) Virus Transduction Reagent. Simply mix with virus to see 2-fold or greater (depending on cell type) transduction efficiencies over polybrene addition.
Or try our newer TransDux MAX™ Virus Transduction Reagent for an even greater increase in infectivity.
- High transduction efficiency
- Broad cell type compatibility
- Minimal hands-on time
How It Works
Get higher transduction efficiencies with minimal hands-on time
Simply combine culture medium with TransDux to a final concentration of 1x, add to cells, and then add virus. Swirl to mix, and proceed with the transduction as usual—72-hours post transduction, the viral genome will be integrated into the host cell genome.
Supporting Data
Increase transduction efficiencies with TransDux
Figure 1. Our original TransDux Reagent increases transduction efficiencies at least 2-fold compared to polybrene. Transduction of either HepG2 cells (top panels) or HT1080 cells (bottom panels) with the addition of polybrene (left two panels) or TransDux (middle two panels). The right two panels show quantitative measures of infectivity using the Global UltraRapid Titer Kit. Both imaging and infectivity data show that TransDux increased the infectivity of lentivirus in both cell types as compared to polybrene.
Resources
Citations
- Eisfeld, AK, et al. (2017) Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia.. Leukemia.2017 Jun 1; 31(6):1278-1285. PM ID:27843138
- Song, R, et al. (2017) An epigenetic regulatory loop controls pro-osteogenic activation by TGF-β1 or bone morphogenetic protein 2 in human aortic valve interstitial cells. J. Biol. Chem..2017 May 26; 292(21):8657-8666. PM ID:28377507
- Li, P, et al. (2017) SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells. Int. J. Mol. Med..2017 May 1; 39(5):1127-1136. PM ID:28339017
- Song, R, et al. (2017) Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves. J Am Heart Assoc.2017 Apr 24; 6(4). PM ID:28438736
- Takahashi, H, et al. (2017) Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells. Oncogene.2017 Mar 27;. PM ID:28346428
- Lin, ZY, et al. (2017) MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer. Mol. Cancer.2017 Feb 27; 16(1):48. PM ID:28241827
- Mo, RJ, et al. (2017) Decreased HoxD10 expression promotes a proliferative and aggressive phenotype in prostate cancer. Curr. Mol. Med..2017 Feb 19;. PM ID:28231752
- Zeng, Q, et al. (2017) Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc. Natl. Acad. Sci. U.S.A..2017 Feb 14; 114(7):1631-1636. PM ID:28137840
- Swiercz, R, et al. (2017) Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption. Oncotarget.2017 Jan 10; 8(2):3528-3541. PM ID:27974681
- Lopez, CM. (2017) MiR-34a Regulates the Invasive Capacity of Canine Osteosarcoma Cell Lines. Thesis.;. Link:Thesis
- Mathew, RS, et al. (2016) A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory. Elife.2016 Dec 21; 5. PM ID:28001126
- Murai, J, et al. (2016) Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition. Oncotarget.2016 Nov 22; 7(47):76534-76550. PM ID:27708213
- Bajaj, J, et al. (2016) CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell.2016 Nov 14; 30(5):792-805. PM ID:27908736
- Zhou, A, et al. (2016) RNA Binding Protein HuR Regulates Cardiac Sodium Channel Gene (SCN5A) Expression Through Transcriptional and Post-Transcriptional Pathways. Circulation.2016 Nov 11; 134(1):A14386. Link:Circulation
- Scott, MT, et al. (2016) Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition. Cancer Discov.2016 Nov 1; 6(11):1248-1257. PM ID:27630125
- Sprowl-Tanio, S, et al. (2016) Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab.2016 Oct 12; 4:20. PM ID:27729975
- Fenger, JM, et al. (2016) MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines. BMC Cancer.2016 Oct 10; 16(1):784. PM ID:27724924
- Li, Q, et al. (2016) High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays. Protocol.2016 Oct 8;:1-34. Link:Protocol
- Chen, Y, et al. (2016) Calcineurin β protects brain after injury by activating the unfolded protein response. Neurobiol. Dis..2016 Oct 1; 94:139-56. PM ID:27334877
- Li, JZ, et al. (2016) MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma. Oncotarget.2016 Sep 6; 7(36):58218-58233. PM ID:27533461
System Biosciences,简称SBI，美国加州湾区新成立的生技公司，致力于独特、创新生物技术之开发，以研发利于基因及蛋白质功能鉴定、研究之崭新方法和工具为宗旨。 现阶段研发重心为RNA干扰（RNAi）研究之相关工具。 System Biosciences (SBI) 致力于开发独特、革新的技术，为客户研究蛋白组学和基因组学功能提供研究工具。SBI 是专业的慢病毒产品公司，提供基于慢病毒的所有相关产品、质粒、试剂盒及相关配套试剂和慢病毒延伸产品如IPS细胞多功能性诱导试剂盒和RNAi筛选文库。
SBI focuses on developing unique, innovative technologies that provide researchers with the tools to investigate and understand genomic and proteomic function. Our mission is to provide tools for the genome-wide analysis of the mechanisms that regulate cellular processes and biological responses.
Headquartered in Palo Alto about 30 miles south of San Francisco, SBI is geographically surrounded by highly successful research biotech companies (e.g., Affymetrix, Life Technologies, and Genentech) and some of the premier life science institutes in the world, including Stanford and the University of California, San Francisco.
As a small private biotechnology company, SBI capitalizes on a rich network of consultants and colleagues and continually collaborates to accelerate its development of innovative and novel applications. Currently, SBI has partnerships with over thirty scientists from several institutes.System Biosciences (SBI) consists of a highly motivated team committed to realizing the potential of its mission to develop and bring to market unique and innovative technology to investigate and understand genomic and proteomic function.
Possessing a diverse range of experience and knowledge, SBI's management and staff bring the skills, talent, and interest needed to support the company's continuing rapid growth.
A strong and proven background in creative research and product development with proficiency in genetic analysis, microarray technology, and cell biology
Extensive business development and management experience
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Expertise in developing, marketing, and supporting consistent, high-quality research products
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